Historically 'safer' tramadol more likely than other opioids to result in prolonged use

Surgical patients receiving the opioid tramadol have a somewhat higher risk of prolonged use than those receiving other common opioids, new Mayo Clinic research finds. However, the Drug Enforcement Administration (DEA) classifies tramadol as a Schedule IV controlled substance, meaning it’s considered to have a lower risk of addiction and abuse than Schedule II opioids, such as oxycodone and hydrocodone.
Source: EurekaAlert, https://www.eurekalert.org