Cofilin may be early culprit in tauopathy process leading to brain cell death

Abnormal accumulations of amyloid plaques and tau neurofibrillary tangles are both needed to drive the death of brain cells, or neurons. But scientists still have a lot to learn about how amyloid impacts tau to promote widespread neurotoxicity, which destroys cognitive abilities like thinking, remembering and reasoning in patients with Alzheimer’s. While investigating the molecular relationship between amyloid and tau, University of South Florida neuroscientists discovered that the Aβ-activated enzyme cofilin plays an essential intermediary role in worsening tau pathology.
Source: EurekaAlert,